This paper identifies the role, conditions for engagement, and contributions of institutional investors in infrastructure projects in the Latin American and Caribbean (LAC) region. Institutional investors are nonbank organizations that invest on behalf of their members, such as pension funds, mutual funds, endowments, and insurers. The paper is based on twelve case studies of specific infrastructure equity investments by institutional investors that have shown substantial sustainability performance, as measured by the Institute for Sustainable Infrastructure’s Envision sustainability rating system. We follow a hybrid research approach, including both quantitative and qualitative data analysis components. The quantitative data analysis evaluates Envision project performance and scores, while the qualitative data analysis researches the conditions under which institutional investors were engaged in infrastructure projects.